Detection of impurities by heart cutting using the Agilent 1290 Infi nity 2 D - LC Solution Application
نویسنده
چکیده
This Application Note demonstrates the capability of the Agilent 1290 Infi nity 2D-LC Solution for heart-cutting applications. As an example, a minor impurity is resolved by heart cutting from a co-eluting main compound. The minor impurity, which is isolated on a second-dimension column after heart cutting, is verifi ed by additional spiking and statistical evaluation of the separation performance. Author Edgar Naegele Agilent Technologies, Inc. Waldbronn, Germany mAU 40 60 80 100 120 140
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